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2022

Highlights of Biomedical Research

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December 2022

Microbiology and Hygiene

First author: Clara Magnus

Senior author: Prof. Dr. med. Barbara Schmidt



Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab


Magnus C.L., Hiergeist A, Schuster P, Rohrhofer A, Medenbach J, Gessner A, Peterhoff D, Schmidt B.


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November 2022

Internal Medicine II - Cardiology, Pneumology, Internal Intensive Care Medicine

First authors: Dr. med. Simon Lebek, Dr. med. Philipp Hegner

Senior author: Prof. Dr. med. Stefan Wagner



NaV1.8 dysregulates Na and Ca leading to arrhythmias in patients with sleep-disordered breathing


Lebek S*, Hegner P*, Hultsch R, Rohde J, Rupprecht L, Schmid C, Sossalla S, Maier L.S., Arzt M, Wagner S.

*These authors contributed equally to this work


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October 2022

Internal Medicine III - Haematology and Internal Oncology

First author: Dr. med. Peter Siska



Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo, eBIOMedicine


Siska P.J, J, Matos C, Singer K, Berger R.S, Dettmer K, Oefner P.J, Cully M.D, Wang Z, QuinnII W.J, Oliff K.N, Wilkins B.J, Christensen L.M, Wang L.W, Hancock W.W, Baur J.A, Levine M.H, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier U.H.


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September 2022

Dermatology

First author: Antonia F?rch

Senior author: Prof. Dr. Stephan Schreml



Expression of proton-sensitive GPR31, GPR151, TASK1 and TASK3 in common skin tumors


F?rch A, Wallner S, Zeman F, Ettl T, Brochhausen C, Schreml S.


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August 2022

Orthopaedics

First author: Dr. med. Dr. med. univ. Julia G?tz

Senior author: Dr. med. Jens Schaumburger



Animal experimental investigation on the efficacy of antibiotic therapy with linezolid, vancomycin, cotrimoxazole, and rifampin in treatment of periprosthetic knee joint infections by MRSA


J. Goetz, V. Keyssner, F. Hanses, F. Greimel, F. Lei?, T. Schwarz, H-R. Springorum, J. Grifka, J. Schaumburger.


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July 2022

Psychiatry and Psychotherapy

First author: Julian Triebelhorn

Senior author: Prof. Dr. rer. nat. Christian Wetzel



Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties


Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel C.H.


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June 2022

Orthodontics

First author: PD Dr. med. Dr. med. dent. Christian Kirschneck

Senior author: PD Dr. Agnes Schr?der



Myeloid HIF1α Is involved in the extent of orthodontically induced tooth movement.


Kirschneck C, Stra?mair N, Cieplik F, et al.


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May 2022

Internal Medicine II - Cardiology, Pneumology and Internal Intensive Care Medicine

Senior author: Prof. Dr. med. Samuel Sossalla



Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure


Bengel P, Dybkova N, Tirilomis P, Ahmad S, Hartmann N , Mohamed B.A, Krekeler M.C, Maurer W, Pabel S, Trum M, Mustroph J, Gummert J, Milting H, Wagner S, Ljubojevic-Holzer S, Toischer K, Maier L.S, Hasenfuss G, Streckfuss-B?meke K, Sossalla S.


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April 2022

Neurology / Microbiology and Hygiene

First author: Dr. med. Bernhard Neumann

Senior author: Dr. med. Markus Bauswein



Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections


Neumann B; Angstwurm K, Linker R.A, Knoll G, Eidenschink L, Rubbenstroth D, Schlottau K, Beer M, Schreiner P, Soutschek E, B?hmer M.M, Lampl B.M.J, Matthias Pregler M, Alexander Scheiter A, Katja Evert K, Zoubaa S,? M.J. Riemenschneider, Asbach B, Gessner A, Niller H.N, Schmidt B, Bauswein M.


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March 2022

Internal Medicine III - Haematology and Internal Oncology

First author: Dr. Peter Siska

Senior author: Prof. Dr. med. Kathrin Renner-Sattler



Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone


Peter J. Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, Jana Klitzke, Marian Sch?n, Jakob Simeth, Josef K?stler, Heiko Siegmund, Ines Ugele, Michael Paulus, Alexander Dietl, Kristina Kolodova, Louisa Steines, Katharina Freitag, Alice Peuker, Gabriele Sch?nhammer, Johanna Raithel, Bernhard Graf, Florian Geismann, Matthias Lubnow, Matthias Mack, Peter Hau, Christopher Bohr, Ralph Burkhardt, Andre Gessner, Bernd Salzberger, Ralf Wagner, Frank Hanses, Florian Hitzenbichler, Daniel Heudobler, Florian Lüke, Tobias Pukrop, Wolfgang Herr, Daniel Wolff, Rainer Spang, Hendrik Poeck, Petra Hoffmann, Jonathan Jantsch, Christoph Brochhausen, Dirk Lunz,?Michael Rehli, Marina Kreutz, and Kathrin Renner


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February 2022

Dental Conservation and Periodontology

First author: Xiaojun Mao

Senior author: PD Dr. Fabian Cieplik



Colonization of helicobacter pylori in the oral cavity – an endless controversy?


Mao X, Jakubovics N.S., B?chle M, Buchalla W, Hiller K.A, Maisch T, Hellwig E, Kirschneck C, Gessner A, Al-Ahmad A, Cieplik F.


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January 2022

Internal Medicine III - Haematology and Internal Oncology

First author: Dr. med. Elisabeth Meedt

Senior author: PD. Dr. med. Daniela Weber



Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation


Meedt E, Hiergeist A, Gessner A, et al.


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Highlights


UR - University of Regensburg
Faculty of Medicine

University Hospital
Franz-Josef-Strau?-Allee 11
93053 Regensburg