Long Noncoding RNAs in Tissue Homeostasis and Disease

Research in the Kretz lab focuses on understanding the roles of long non-coding RNAs (lncRNAs) in regulation of mature tissue homeostasis, using human organotypic epidermis as a model system.

We are investigating the mechanisms by which lncRNAs control progenitor cell maintenance and differentiation in normal and neoplastic epidermis:? ? ? ? ? ? ? ? ? ? ? ? ??

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Recently, we have shown that several lncRNAs participate in controlling the intricate balance between progenitor cells undergoing continual regeneration in the basal layer and highly differentiated cells forming the epidermal permeability barrier