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Research

Institute for Biophysics and physical Biochemistry

Biochemistry II


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In the focus of our research are enzymes, which are elaborate proteins that catalyse cellular reactions with high specificity and efficiency.?


We are using rational design and directed evolution to

  • engineer the stability and catalytic activity of enzymes,
  • experimentally reconstruct the natural evolution of enzymes,
  • assign functions to uncharacterised enzymes,
  • characterize allosteric interactions within multi-enzyme complexes
  • and light-regulate enzymatic activity.

To this end, we apply a broad range of experimental and computational methods.


Our work is part of the following research clusters:


  1. Fakult?t für Biologie und Vorklinische Medizin
  2. Faculty Research

Biochemistry II

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The (βα)8-barrel fold