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Team

Biochemistry II

Dr. Andrea Hupfeld (née Kneuttinger)


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Leader

Curriculum Vitae

Dr. Andrea Kneuttinger

Andrea Hupfeld (née Kneuttinger) is a research group leader in Biochemistry at the University of Regensburg. Her group focuses on the engineering of photocontrol in enzymes by using a combined organic chemistry, chemical biology, enzymology, and protein engineering approach.

Already in high school Andrea became fascinated by molecular mechanisms and therefore studied Biochemistry at the Technical University of Munich. In 2010, she obtained her Master degree with high distinction and was awarded with the Jürgen-Manchot prize for characterizing a DNA repair enzyme. Motivated by this interdisciplinary work at the interface of organic chemistry and enzymology, she continued the project in her doctorate with Thomas Carell at the Ludwig-Maximilians-University of Munich until 2014.

Driven by the desire to acquire additional professional expertise and life experience outside research, she honed her teaching skills both as a Science teacher in Southampton (England) and a lecturer on Scientific English in Regensburg (Germany), as well as her leadership skills by qualifying as project management specialist.?

In 2016 Andrea resumed her career in research as a PostDoc with Reinhard Sterner at the University of Regensburg, where she achieved to photocontrol enzyme activity and allostery reversibly and with high light-regulation factors by the incorporation of photo-responsive unnatural amino acids.

In 2020 she started her habilitation as well as founded her own research group in which she resumes her work on the light-regulation of proteins, in particular enzymes, using unnatural amino acids - a field, which she dubbed "photoxenoprotein engineering" in 2022.

Education

2020 –

HABILITATION IN BIOCHEMISTRY
University of Regensburg

2010 – 2014

DISSERTATION IN ORGANIC CHEMISTRY
Ludwig-Maximilians-University Munich

2008 – 2010

“MASTER OF SCIENCE” IN BIOCHEMISTRY
Technical University Munich

2005 – 2008

“BACHELOR OF SCIENCE” IN BIOCHEMISTRY
Technical University Munich
Career

present

GROUP LEADER
Institute of Biophysics and Physical Biochemistry,
University of Regensburg

2016 – 2019

POSTDOC
Institute of Biophysics and Physical Biochemistry,
University of Regensburg

2015 – 2016

LECTURER
Department of Chemistry and Pharmacy,
University of Regensburg

2014 – 2015

TEACHER
Science Department,
Wildern School Southampton
Awards

2011

J?RGEN MANCHOT AWARD
Technical University Munich

Members

Doctoral Students

Caroline Hiefinger

Caroline Hiefinger

Email
Phone: +49-941-943-1639
Room: E3_1.307

Member since: Sep 2020

Sabrina Mandl

Sabrina Mandl

Email
Phone: +49-941-943-1639
Room: E3_1.307

Member since: Sep 2020

Mona Wieland

Email
Phone: +49-941-943-3041
Room: E3_1.305

Member since: Dec 2020


Master Students

Elena Adlmanninger

Email

Room: E3_1.105

Member since: Jun?2024


Alumni

We thank all former colleagues who contributed to our vision of engineering photocontrol in enzymes.

Master Students Publications
2022 - 2023 Barbara Maiwald (née Hufnagl)
2021 - 2022 Michael Bartl
2021 Johanna Rein
2020 - 2021 Fjoralba Zeqiri
2020 - 2021 Barbara Gaim [11]
2018?– 2019 Stefanie Zwisele [11]
2017?– 2018 Thomas Kinateder [11, 13]
2017?– 2018 Philipp Bittner [10]
2016?– 2017 Martin Winter [9]


  1. Fakult?t für Biologie und Vorklinische Medizin
  2. Faculty Research

Engineering of Photocontrol in Enzymes

Group of
Dr. Andrea Hupfeld
(née Kneuttinger)

Dr. Andrea Kneuttinger

Email
Phone: +49-941-943 7439
Room: E3_1.315

Curriculum Vitae
ORCID