Research
Research
In the last decades, the research field on RNAs developed dramatically and the role of different types of RNAs to pathologies became obvious. LncRNAs and other non-coding RNAs like circular RNAs and miRNAs are highly expressed in the brain and associated with a wide range of neurodevelopmental, neurodegenerative and psychiatric diseases. However, the involvement of non-coding RNAs, especially miRNAs and lncRNAs, in social fear and social fear extinction is still unknown.
In my project, I want to assess the involvement of coding and non-coding RNAs in SFC-induced social fear and its extinction. Therefore, I use the social fear condition paradigm to induce symptoms of social in fear in mice, and Total RNA Sequencing to determine involved RNAs. In this context, I also want to map a comprehensive path from OXTR activation to protein synthesis changes via pre- and post-transcriptional regulation through non-coding RNAs, resulting in altered behaviour of the animals. Used techniques include for example RNA/protein extraction, Next Generation Sequencing, social fear conditioning and behavioural tests, Western blots, qPCRs, immunohistochemistry, stereotactic implantations and intracerebral microdialysis.
Profile
Profile
Since 2017
PhD student in neurobiology/biochemistry in Prof. Dr. Inga D. Neumann’s/ Prof. Dr. Gunter Meister’s group, Department of Molecular and Behavioural Neurobiology/ Biochemistry I, University of Regensburg, Germany
?at the University of Regensburg, Germany.
Funded project by the GRK2174 (DFG)
2014-2016
M.Sc. in Biology at the University of Regensburg with focus on Biochemistry, Human Molecular Biology/Anatomy and Human Genetics
Thesis: “Effects of Retinoschisin on Localization, Thermostability and Substrate Affinity of the Na/K-ATPase - Research in Pathological Processes in X-linked Juvenile Retinoschisis”, Prof. Dr. Bernhard Weber, Institute of Human Genetics, University of Regensburg, Germany
2011-2014
B.Sc. in Biology at the University of Regensburg
Thesis: “Dose-dependent effects of chronic oxytocin applications on anxiety-related behaviour and gene expression in rats”, Prof. Inga D. Neumann, Department of Molecular and Behavioural Neurobiology, University of Regensburg, Germany
Born September 1991, Burglengenfeld, Germany
Publications
Publications
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Karolina Pl?ssl, Melanie Royer, Sarah Bernklau, Neslihan N. Tavraz, Thomas Friedrich, Jens Wild, Bernhard H. F. Weber, and Ulrike Friedrich; 2017; Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.; Molecular Biology of the CellVol. 28, No. 16
