Topic
Ribosomes catalyze the translation of mRNA into proteins. Thereby, they have a key role in gene expression, cell growth and cell cycle progression. Ribosomes are large ribonucleo-protein complexes (RNP’s) consisting? of? ribosomal RNA (rRNA) and a large number (>50) of ribosomal proteins (r-proteins). Recent years brought detailed insights into the 3D-organisation of rRNA and r-proteins in mature ribosomes. In addition, it became evident that a significant proportion of the genome of an unicellular eukaryote (bakers yeast?S. cerevisiae) codes for factors which are required for making ribosomes. Taking yeast as model system, we use a variety of in vivo and in vitro approaches to study the interrelationship between important? processes??in eukaryotic?ribosome biogenesis, namely RNA synthesis, RNA processing, RNA folding, RNP assembly, and intracellular transport of? RNP precursors.
Team
 | Joachim Griesenbeck, Principal investigatoremail:? joachim.griesenbeck (at) ur.de |
 | Philipp Milkereit, Principal investigatoremail:? philipp.milkereit (at) ur.de |
 | Herbert Tschochner, Principal investigatoremail:? herbert.tschochner (at) ur.de |
Publications
Funding
?
-
since July 2011
DFG collaborative research Center SFB960 at the University of Regensburg: Ribosome formation: principles of RNP biogenesis and control of their function
Project B1: Analyses of eukaryotic ribosome assembly?
